A Seven-Year Microbiological and Molecular Study of Bacteremias Due to Carbapenemase-Producing Klebsiella Pneumoniae: An Interrupted Time-Series Analysis of Changes in the Carbapenemase Gene's Distribution after Introduction of Ceftazidime/Avibactam.

ABSTRACT:

Background

Ceftazidime/avibactam (CZA) is a new option for the treatment of KPC-producing Klebsiella pneumoniae. The aim of this study was to determine resistance patterns and carbapenemase genes among K. pneumoniae (CP-Kp) bacteremic isolates before and after CZA introduction.

Methods

K. pneumoniae from blood cultures of patients being treated in a Greek university hospital during 2015-21 were included. PCR for bla_KPC, bla_VIM, bla_NDM and bla_OXA-48 genes was performed.

Results

Among 912 K. pneumoniae bacteremias: 725 (79.5%) were due to carbapenemase-producing isolates; 488 (67.3%) carried bla_KPC; 108 (14.9%) bla_VIM; 100 (13.8%) bl

SUBMITTER: Papadimitriou-Olivgeris M 

PROVIDER: S-EPMC9598502 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature