Therapeutic Potential of Adipose Stem Cell-Derived Conditioned Medium on Scar Contraction Model.

ABSTRACT: Scars are composed of stiff collagen fibers, which contract strongly owing to the action of myofibroblasts. To explore the substances that modulate scar contracture, the fibroblast-populated collagen lattice (FPCL) model has been used. However, the molecular signature of the patient-derived FPCL model has not been verified. Here, we examined whether the patient-derived keloid FPCL model reflects scar contraction, analyzing detailed gene expression changes using comprehensive RNA sequencing and histological morphology, and revealed that these models are consistent with the changes during human scar contracture. Moreover, we examined whether conditioned media derived from adipose stem cells (ASC-CM) suppress the scar contracture of the collagen disc. Detailed time-series measurements of chan

SUBMITTER: Imai Y 

PROVIDER: S-EPMC9598573 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature