The Safety and Efficacy of Phage Therapy: A Systematic Review of Clinical and Safety Trials.

ABSTRACT: Trials of phage therapy have not consistently reported efficacy. This contrasts with promising efficacy rates from a sizeable and compelling body of observational literature. This systematic review explores the reasons why many phage trials have not demonstrated efficacy. Four electronic databases were systematically searched for safety and/or efficacy trials of phage therapy. Sixteen trials of phage therapy were included, in which 378 patients received phage. These were divided into historical (pre-2000; N = 3; n = 76) and modern (post-2000; N = 13; n = 302) trials. All 13 modern trials concluded that phage therapy was safe. Six of the 13 modern trials were exclusively safety trials. Seven modern trials investigated both safety and efficacy; efficacy was observed in two. Two

SUBMITTER: Stacey HJ 

PROVIDER: S-EPMC9598614 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature