Exploring Epigallocatechin-3-Gallate Autoxidation Products: Specific Incubation Times Required for Emergence of Anti-Amyloid Properties.

ABSTRACT: Amyloidogenic protein/peptide aggregation into fibrillar aggregates is associated with multiple amyloidoses, including widespread neurodegenerative disorders. Despite years of research and a well-understood mechanism, there are still very few treatments available for the increasing number of amyloid-related disorders. In recent years, the search for potential anti-aggregation compounds has shifted toward naturally occurring molecules, with one of the most promising being epigallocatechin-3-gallate (EGCG). This polyphenolic compound was shown to inhibit the aggregation of several amyloidogenic proteins/peptides, including amyloid-beta (related to Alzheimer's disease) and alpha-synuclein (related to Parkinson's disease). However, multiple reports have indicated its limited stability under ph

SUBMITTER: Ziaunys M 

PROVIDER: S-EPMC9598636 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature