Interplay between Partial EMT and Cisplatin Resistance as the Drivers for Recurrence in HNSCC.
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ABSTRACT:
SUBMITTER: Ingruber J
PROVIDER: S-EPMC9598677 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
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Interplay between Partial EMT and Cisplatin Resistance as the Drivers for Recurrence in HNSCC.
Ingruber Julia J Dudas Jozsef J Sprung Susanne S Lungu Bianca B Mungenast Felicitas F
Biomedicines 20221005 10
This study aims to investigate the role of partial epithelial to mesenchymal transition (pEMT)-related proteins in modulating Cisplatin resistance in head and neck squamous cell carcinoma (HNSCC). SCC-25 cells were pre-treated with TGF-beta1 followed by transient Krüppel-like Factor 4 (KLF4)-overexpression and Cisplatin treatment. Cell growth, cell morphological changes and cell migration were assessed using Juli BR live cell video-microscopy. In addition, Ki-67 and Slug immunostaining and follo ...[more]
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