Synergistic Activity of Tetrandrine and Colistin against mcr-1-Harboring Escherichia coli.

ABSTRACT: Before the emergence of plasmid-mediated colistin resistance, colistin was once considered the last drug of choice for infections caused by carbapenem-resistant bacteria. Currently, researchers are relentlessly exploring possible alternative therapies that could efficiently curb the spread of drug resistance. In this study, we aim to investigate the synergistic antibacterial activity of tetrandrine in combination with colistin against mcr-1-harboring Escherichia coli. We examined the antibacterial activity of tetrandrine in combination with colistin in vivo and in vitro and examined the bacterial cells by fluorescence, scanning, and transmission electron microscopy (TEM) to explore their underlying mechanism of action. We further performed a computational analysis of MCR-1 pr

SUBMITTER: Shafiq M 

PROVIDER: S-EPMC9598752 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature