The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis.

ABSTRACT: Polycystic ovary syndrome (PCOS) and endometriosis are frequent diseases of the female reproductive tract causing high morbidity as they can significantly affect fertility and quality of life. Adipokines are pleiotropic signaling molecules secreted by white or brown adipose tissues with a central role in energy metabolism. More recently, their involvement in PCOS and endometriosis has been demonstrated. In this review article, we provide an update on the role of adipokines in both diseases and summarize previous findings. We also address the results of multi-omics approaches in adipokine research to examine the role of single nucleotide polymorphisms (SNPs) in genes coding for adipokines and their receptors, the secretome of adipocytes and to identify epigenetic alterations of adipokine ge

SUBMITTER: Schuler-Toprak S 

PROVIDER: S-EPMC9598769 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature