Ontology highlight
ABSTRACT:
SUBMITTER: Mascaro M
PROVIDER: S-EPMC9598840 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Mascaró Marilina M Alonso Exequiel G EG Schweitzer Karen K Rabassa Martín E ME Carballido Jessica A JA Ibarra Agustina A Alonso Eliana N EN Bermúdez Vicente V Fernández Chavez Lucía L Coló Georgina P GP Ferronato María Julia MJ Pichel Pamela P Recio Sergio S Clemente Valentina V Fermento Maria Eugenia ME Facchinetti María Marta MM Curino Alejandro C AC
Antioxidants (Basel, Switzerland) 20221021 10
Head and neck squamous cell carcinoma (HNSCC) is a remarkably heterogeneous disease with around 50% mortality, a fact that has prompted researchers to try new approaches to improve patient survival. Hemoxygenase-1 (HO-1) is the rate-limiting step for heme degradation into carbon monoxide, free iron and biliverdin. We have previously reported that HO-1 protein is upregulated in human HNSCC samples and that it is localized in the cytoplasmic and nuclear compartments; additionally, we have demonstr ...[more]