ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone Harboring bla_NDM Replaced a bla_KPC Clone in a Tertiary Hospital in China.

ABSTRACT: The nosocomial spread of carbapenem-resistant Enterobacterales (CRE) is extremely common, resulting in severe burdens on healthcare systems. In particular, the high-risk Klebsiella pneumoniae ST11 strain has a wide endemic area in China. The current study describes the results of continuous monitoring of CRE genotypes and phenotypes in a tertiary hospital in North China from 2012 to 2020. A total of 160 isolates were collected, including 109 Klebsiella. pneumoniae (68.13%), 29 Escherichia coli (26.60%), 12 Enterobacter cloacae (7.50%), and 10 other strains (6.25%). A total of 149 carbapenemase genes were detected, of which blaKPC-2 (51.0%) was the most common, followed by blaNDM-1 (22.82%), and blaNDM-5 (23.49%). Based on multi-locus sequence typing, the ST11 strain (66.1%) dominates K. pn

SUBMITTER: Duan Q 

PROVIDER: S-EPMC9598860 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature