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A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment.


ABSTRACT: Brain-derived neurotrophic factor (BDNF), as the most widely distributed and widely studied neurotrophic factor in the mammalian brain, plays a key role in depression and the mechanisms of action for antidepressants. Currently, there is a large number of studies on the role of BDNF in the pathogenesis and therapeutic mechanism of depression. The quantity and quality of these studies, however, are unknown. To give beginners a quicker introduction to this research topic, we therefore performed a bibliometric analysis. A total of 5300 publications were included. We obtained the publications on this topic from the Web of Science database, and a variety of bibliographic elements were collected, including annual publications, authors, countries/regions, institutions, journals, and keywords. Moreover, we found that oxidative stress and neuroinflammation are the hotspots in the field in very recent years. Collectively, this study provides a comprehensive summary and analysis on the role of BDNF in depression and its treatment and offers meaningful values for beginners on this topic.

SUBMITTER: He T 

PROVIDER: S-EPMC9599058 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment.

He Teng T   Wu Zifeng Z   Zhang Xinying X   Liu Hanyu H   Wang Yuanyuan Y   Jiang Riyue R   Liu Cunming C   Hashimoto Kenji K   Yang Chun C  

Biomolecules 20221012 10


Brain-derived neurotrophic factor (BDNF), as the most widely distributed and widely studied neurotrophic factor in the mammalian brain, plays a key role in depression and the mechanisms of action for antidepressants. Currently, there is a large number of studies on the role of BDNF in the pathogenesis and therapeutic mechanism of depression. The quantity and quality of these studies, however, are unknown. To give beginners a quicker introduction to this research topic, we therefore performed a b  ...[more]

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