Genetic Markers for Thrombophilia and Cardiovascular Disease Associated with Multiple Sclerosis.

ABSTRACT: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) with an unknown etiology, although genetic, epigenetic, and environmental factors are thought to play a role. Recently, coagulation components have been shown to provide immunomodulatory and pro-inflammatory effects in the CNS, leading to neuroinflammation and neurodegeneration. The current study aimed to determine whether patients with MS exhibited an overrepresentation of polymorphisms implicated in the coagulation and whether such polymorphisms are associated with advanced disability and disease progression. The cardiovascular disease (CVD) strip assay was applied to 48 MS patients and 25 controls to analyze 11 genetic polymorphisms associated with thrombosis and CVD. According to our resul

SUBMITTER: Hadjiagapiou MS 

PROVIDER: S-EPMC9599167 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature