Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts.

ABSTRACT: Higher blood and sputum eosinophil counts are associated with a greater response to corticosteroids in COPD. Low blood eosinophil counts exhibit greater stability over time whereas higher counts demonstrate more variability. Stability of airway eosinophil levels is less well understood. We have studied the stability of sputum eosinophil counts. Differential cell count data for COPD patients (n = 100) were analysed. Subjects with two sputum eosinophil counts, 6 months apart, were included in the analysis. Patients were stratified based on baseline sputum eosinophil count into 'low', 'intermediate' and 'high' groups: eosinophil^LOW (<1%), eosinophil^INT (1-3%) and eosinophil^HIGH (≥3%). Sputum eosinophil counts showed good stability (rho = 0.61, p</

SUBMITTER: Beech A 

PROVIDER: S-EPMC9599170 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature