PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate.

ABSTRACT: Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid phosphatase which opposes the activation of the oncogenic PI3K-AKT signalling network. However, PTEN also has additional potential mechanisms of action, including protein phosphatase activity. Using a mutant enzyme, PTEN Y138L, which selectively lacks protein phosphatase activity, we characterised genetically modified mice lacking either the full function of PTEN in the prostate gland or only lacking protein phosphatase activity. The phenotypes of mice carrying a single allele of either wild-type Pten or Pten^Y138L in the prostate were similar, with common prostatic intraepithelial neoplasia (PIN) and similar gene expression profiles. However, t

SUBMITTER: Wise HM 

PROVIDER: S-EPMC9599176 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature