T Lymphocyte Serotonin 5-HT₇ Receptor Is Dysregulated in Natalizumab-Treated Multiple Sclerosis Patients.

ABSTRACT: Serotonin (5-HT) is known as a potent immune cell modulator in autoimmune diseases and should be protective in the pathogenesis of multiple sclerosis (MS). Nevertheless, there is limited knowledge about receptors involved in 5-HT effects as well as induced mechanisms. Among 5-HT receptors, the 5-HT₇ receptor is able to activate naïve T cells and influence the inflammatory response; however, its involvement in the disease has never been studied so far. In this study, we collected blood sample from three groups: acute relapsing MS patients (ARMS), natalizumab-treated MS patients (NTZ), and control subjects. We investigated the 5-HT₇ expression on circulating lymphocytes and evaluated the effects of its activation on cytokine production with peripheral blood mononuclear

SUBMITTER: Reverchon F 

PROVIDER: S-EPMC9599221 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature