Impacts of Menstruation, Community Type, and an Oral Yeast Probiotic on the Vaginal Microbiome.

ABSTRACT: A healthy state of the vaginal microbiome can prevent vaginal disease and promote successful fertilization and healthy pregnancies. Little is known about the stability of the vaginal microbiome and the influence of factors such as diet and probiotics. While less explored, yeast probiotics have an interesting potential because of their immunomodulatory and pathogen inhibition capacities. In this study, we investigated the impact of the oral yeast probiotic Saccharomyces cerevisiae CNCM I-3856 on the vaginal microbiomes of 52 healthy women using 16S and internal transcribed spacer (ITS) amplicon sequencing and quantitative PCR (qPCR). The vaginal fungal loads remained low, even after oral yeast supplementation, complicating the analysis of the vaginal mycobiome. Lactobacillus crispatus and L

SUBMITTER: Oerlemans E 

PROVIDER: S-EPMC9599324 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature