Noninvasive Characterization of Functional Pathways in Layer-Specific Microcircuits of the Human Brain Using 7T fMRI.

ABSTRACT: Layer-specific cortical microcircuits have been explored through invasive animal studies, yet it is not possible to reliably characterize them functionally and noninvasively in the human brain. However, recent advances in ultra-high-field functional magnetic resonance imaging (fMRI) have made it feasible to reasonably resolve layer-specific fMRI signals with sub-millimeter resolution. Here, we propose an experimental and analytical framework that enables the noninvasive functional characterization of layer-specific cortical microcircuits. Specifically, we illustrate this framework by characterizing layer-specific functional pathways in the corticogeniculate network of the human visual system by obtaining sub-millimeter fMRI at 7T using a task which engages the magnocellular pathway between

SUBMITTER: Deshpande G 

PROVIDER: S-EPMC9599333 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature