Direct Reprogramming of Mouse Subchondral Bone Osteoblasts into Chondrocyte-like Cells.

ABSTRACT: Treatment of full-thickness articular cartilage defects with exposure of subchondral bone often seen in osteoarthritic conditions has long been a great challenge, especially with a focus on the feasibility of in situ cartilage regeneration through minimally invasive procedures. Osteoblasts that situate in the subchondral bone plate may be considered a potentially vital endogenous source of cells for cartilage resurfacing through direct reprogramming into chondrocytes. Microarray-based gene expression profiles were generated to compare tissue-specific transcripts between subchondral bone and cartilage of mice and to assess age-dependent differences of chondrocytes as well. On osteoblast cell lines established from mouse proximal tibial subchondral bone, sequential screening by co-transducti

SUBMITTER: Li M 

PROVIDER: S-EPMC9599480 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature