The Abundance of Tumor-Infiltrating CD8⁺ Tissue Resident Memory T Lymphocytes Correlates with Patient Survival in Glioblastoma.

ABSTRACT: Glial tumors alone account for 40% of all CNS tumors and present a low survival rate. The tumor microenvironment is a critical regulator of tumor progression and therapeutic effectiveness in glioma. Growing evidence from numerous studies of human solid tumor-infiltrating CD8⁺ T cells indicates that tissue-resident memory T cells (TRM) represent a substantial subpopulation of tumor-infiltrating lymphocytes (TILs). Although it is reported that some types of cancer patients with high immune infiltration tend to have better outcomes than patients with low immune infiltration, it seems this does not happen in gliomas. This study aimed to characterize TRMs cells in the glioma tumor microenvironment to identify their potential predictive and prognostic role and the possible therapeutic

SUBMITTER: La Manna MP 

PROVIDER: S-EPMC9599482 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature