Generation of Dynamic Concentration Profile Using A Microfluidic Device Integrating Pneumatic Microvalves.

ABSTRACT: Generating and maintaining the concentration dilutions of diffusible molecules in microchannels is critical for high-throughput chemical and biological analysis. Conventional serial network microfluidic technologies can generate high orders of arbitrary concentrations by a predefined microchannel network. However, a previous design requires a large occupancy area and is unable to dynamically generate different profiles in the same chip, limiting its applications. This study developed a microfluidic device enabling dynamic variations of both the concentration in the same channel and the concentration distribution in multiple channels by adjusting the flow resistance using programmable pneumatic microvalves. The key component (the pneumatic microvalve) allowed dynamic adjustment of the conce

SUBMITTER: Chen C 

PROVIDER: S-EPMC9599525 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature