CLDN1 Sensitizes Triple-Negative Breast Cancer Cells to Chemotherapy

ABSTRACT:

Simple Summary

Triple-negative breast cancer (TNBC) treatment represents a major challenge in oncology. TNBC evolves into chemotherapy resistance for 60 to 70% of the patients. About 77% of the TNBC displays a lack of claudin-1 (CLDN1), a major tight junction component. We demonstrated that CLDN1 increased the sensitivity of TNBC cell lines to the main chemotherapeutic agents commonly used for breast cancer treatment. Our data support the idea that CLDN1 may be a good predictive chemotherapy response marker to help therapeutic management of TNBC patients. In longer terms, this study could allow new treatment protocols creation aimed to induce CLDN1 expression in TNBCs to increase their sensitivity to chemotherapy.

Abstract

Triple-negative breast cancer (TNBC) is an aggres

SUBMITTER: Lemesle M 

PROVIDER: S-EPMC9599637 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature