Elevated Extracellular HSP72 and Blunted Heat Shock Response in Severe COVID-19 Patients.

ABSTRACT:

Aims

We hypothesized that critically ill patients with SARS-CoV-2 infection and insulin resistance would present a reduced Heat Shock Response (HSR), which is a pathway involved in proteostasis and anti-inflammation, subsequently leading to worse outcomes and higher inflammation. In this work we aimed: (i) to measure the concentration of extracellular HSP72 (eHSP72) in patients with severe COVID-19 and in comparison with noninfected patients; (ii) to compare the HSR between critically ill patients with COVID-19 (with and without diabetes); and (iii) to compare the HSR in these patients with noninfected individuals.

Methods

Sixty critically ill adults with acute respiratory failure with SARS-CoV-2, with or without diabetes, were selected. Noninfected subjects were included fo

SUBMITTER: Borges Russo MK 

PROVIDER: S-EPMC9599720 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature