Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies.

ABSTRACT: Pancreatic cancer remains one of the deadliest forms of cancer with a 5-year survival rate of only 11%. Difficult diagnosis and limited treatment options are the major causes of the poor outcome for pancreatic cancer. The human protein DNAJA1 has been proposed as a potential therapeutic target for pancreatic cancer, but its cellular and biological functions remain unclear. Previous studies have suggested that DNAJA1's cellular activity may be dependent upon its protein binding partners. To further investigate this assertion, the first 107 amino acid structures of DNAJA1 were solved by NMR, which includes the classical J-domain and its associated linker region that is proposed to be vital to DNAJA1 functionality. The DNAJA1 NMR structure was then used to identify both protein and ligand bin

SUBMITTER: Roth HE 

PROVIDER: S-EPMC9599757 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature