Electromotive Enhanced Drug Administration in Oncology: Principles, Evidence, Current and Emerging Applications.

ABSTRACT: Local-regional administration of cytotoxic drugs is an important adjunct to systemic chemotherapy amongst cancer patients. It allows for targeted delivery of agents at high concentration to target sites while minimizing systemic side effects. Despite the pharmacokinetic advantages of the local-regional approach, drug transport into tumor nodules remains limited due to the biophysical properties of these tissues. Electromotive enhanced drug administration (EMDA) represents a potential solution to overcome challenges in local drug transport by applying electric currents. Through electrokinetic phenomena of electromigration, electroosmosis and electroporation, electric currents have been shown to improve drug penetration and distribution in a wide variety of clinical applications. Amongst pat

SUBMITTER: Min JWS 

PROVIDER: S-EPMC9599758 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature