Biological and Exploitable Crossroads for the Immune Response in Cancer and COVID-19.

ABSTRACT: The outbreak of novel coronavirus disease 2019 (COVID-19) has exacted a disproportionate toll on cancer patients. The effects of anticancer treatments and cancer patients' characteristics shared significant responsibilities for this dismal outcome; however, the underlying immunopathological mechanisms are far from being completely understood. Indeed, despite their different etiologies, SARS-CoV-2 infection and cancer unexpectedly share relevant immunobiological connections. In the pathogenesis and natural history of both conditions, there emerges the centrality of the immune response, orchestrating the timed appearance, functional and dysfunctional roles of multiple effectors in acute and chronic phases. A significant number (more than 600) of observational and interventional studies have

SUBMITTER: Vitali L 

PROVIDER: S-EPMC9599827 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature