Precision Medicine in Parkinson's Disease: From Genetic Risk Signals to Personalized Therapy.

ABSTRACT: Understanding the pathophysiology and genetic background of Parkinson's disease (PD) increases the likelihood of developing effective disease-modifying therapeutic strategies. In particular, the discovery of genetic variants causing or increasing the risk for PD has contributed to refining the clinical, biological, and molecular classification of the disease and has offered new insights into sporadic forms. It is even more evident that specific genetic mutations can show different responses to pharmacological and device-aided therapies. To date, several agents acting on multiple PD-causing pathogenic pathways have been tested as disease-modifying strategies, with disappointing results. This may be caused by the recruitment of PD populations whose underlying molecular pathophysiology is het

SUBMITTER: Straccia G 

PROVIDER: S-EPMC9599944 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature