Dynamic Expression of Palmitoylation Regulators across Human Organ Development and Cancers Based on Bioinformatics.

ABSTRACT: Protein palmitoylation is a reversible modification process that links palmitate to cysteine residues via a reversible thioester bond. Palmitoylation exerts an important role in human organ development and tumor progression. However, a comprehensive landscape regarding the dynamic expression of palmitoylation regulators in human organ development remains unclear. In this study, we analyzed the dynamic expression of palmitoylation regulators in seven organ development and eight cancer types based on bioinformatics. We found that the expression levels of most palmitoylation regulators were altered after birth. In particular, ZDHHC7/20/21 exhibited converse expression patterns in multiple cancer types. Survival analysis showed that the poor prognosis in patients with kidney renal clear

SUBMITTER: Jia Z 

PROVIDER: S-EPMC9600046 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature