DLX Genes in the Development and Maintenance of the Vertebrate Skeleton: Implications for Human Pathologies.

ABSTRACT: Skeletal shape and mechanical properties define, to a large extent, vertebrate morphology and physical capacities. During development, skeletal morphogenesis results from dynamic communications between chondrocytes, osteoblasts, osteoclasts, and other cellular components of the skeleton. Later in life, skeletal integrity depends on the regulatory cascades that assure the equilibrium between bone formation and resorption. Finally, during aging, skeletal catabolism prevails over anabolism resulting in progressive skeletal degradation. These cellular processes depend on the transcriptional cascades that control cell division and differentiation in each cell type. Most Distal-less (Dlx) homeobox transcription factors are directly involved in determining the proliferation and diff

SUBMITTER: Levi G 

PROVIDER: S-EPMC9600099 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature