Alterations of Plasma Pro-Inflammatory Cytokine Levels in Children with Refractory Epilepsies.

ABSTRACT: Paediatric epilepsy is a multifaceted neurological disorder with various aetiologies. Up to 30% of patients are considered drug-resistant. The background impact of interfering inflammatory and neuronal pathways has been closely linked to paediatric epilepsy. The characteristics of the inflamed state have been described not only in epilepsies, which are considered prototypes of an inflammatory pathophysiology, but also in patients with drug-resistant epilepsy, especially in epileptic encephalopathies. The imbalance of different cytokine levels was confirmed in several epileptic models. Chemokines are new targets for exploring neuroimmune communication in epileptogenesis, which control leukocyte migration and have a possible role in neuromodulation. Additionally, prostaglandin E2 (PGE2) is a

SUBMITTER: Gakharia T 

PROVIDER: S-EPMC9600205 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature