Radioembolization-Induced Changes in Hepatic [¹⁸F]FDG Metabolism in Non-Tumorous Liver Parenchyma.

ABSTRACT:

Background

[¹⁸F]FDG-PET/CT is increasingly used for response assessments after oncologic treatment. The known response criteria for [¹⁸F]FDG-PET/CT use healthy liver parenchyma as the reference standard. However, the [¹⁸F]FDG liver metabolism results may change as a result of the given therapy. The aim of this study was to assess changes in [¹⁸F]FDG liver metabolism after hepatic ⁹⁰Y resin radioembolization.

Methods

[¹⁸F]FDG-PET/CT scans prior to radioembolization and one and three months after radioembolization (consistent with the PERCIST comparability criteria), as well as ⁹⁰Y-PET/CT scans, were analyzed using 3 cm VOIs. The FDG activity concentration and absorbed dose were measured. A linear mix

SUBMITTER: Braat MN 

PROVIDER: S-EPMC9600277 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature