The Role of m⁶A Modification and m⁶A Regulators in Esophageal Cancer.

ABSTRACT: N⁶-methyladenosine (m⁶A) modification, the most prevalent RNA modification, is involved in all aspects of RNA metabolism, including RNA processing, nuclear export, stability, translation and degradation. Therefore, m⁶A modification can participate in various physiological functions, such as tissue development, heat shock response, DNA damage response, circadian clock control and even in carcinogenesis through regulating the expression or structure of the gene. The deposition, removal and recognition of m⁶A are carried out by methyltransferases, demethylases and m⁶A RNA binding proteins, respectively. Aberrant m⁶A modification and the dysregulation of m⁶A regulators play critical roles in the occurrence and develop

SUBMITTER: Li Y 

PROVIDER: S-EPMC9600289 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature