The role of neoadjuvant chemotherapy in patients with locally advanced colon cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

Controversy persists about neoadjuvant chemotherapy (NAC) within the field of locally advanced colon cancer (LACC). The purpose of this study was to assess the existing and latest literature with high quality to determine the role of NAC in various aspects.

Methods

A comprehensive literature search of the PubMed, Embase, Web of Science, and the Cochrane Library databases was conducted from inception to April 2022. Review Manager 5.3 was applied for meta-analyses with a random-effects model whenever possible.

Results

Overall, 8 studies were included in this systematic review and meta-analysis, comprising 4 randomized controlled trials (RCTs) and 4 retrospective studies involving 40,136 participants. The 3-year overall survival (OS) (HR: 0.90, 95% CI: 0.66-1.

SUBMITTER: Liang Z 

PROVIDER: S-EPMC9600337 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature