The Role of [⁶⁸Ga]PSMA PET/CT for Clinical Suspicion of Prostate Cancer in Patients with or without Previous Negative Biopsy: A Systematic Review.

ABSTRACT: The purpose of the study is to systematically evaluate the evidence regarding the role of [⁶⁸Ga]PSMA PET/CT for clinical suspicions of prostate cancer in patients with or without previous negative biopsy. We performed a critical review of PubMed and Web of Science according to the PRISMA statement. Eighteen publications were selected for inclusion in this analysis. QUADAS-2 evaluation was adopted for quality analyses. [⁶⁸Ga]PSMA-11 was the radiotracer of choice in 15 studies, while [⁶⁸Ga]PSMA-617 was used in another 3. In 8 articles, there was a direct comparison with mpMRI. The total number of patients included was 1379, ranging from 15 to 291, with a median age of 64 years (range: 42-90). The median baseline PSA value was 12.9 ng/mL, ranging from 0.85 to

SUBMITTER: Caracciolo M 

PROVIDER: S-EPMC9600353 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature