Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review.

ABSTRACT: NUT carcinoma is a rare, highly lethal cancer characterized with the rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14, which primarily occurs in the midline organs. Primary pulmonary NUT carcinoma (NC) lacks characteristic clinical manifestations, which leads to the high rate of misdiagnose and nonstandard treatment. To date, fewer than one hundred cases have been reported worldwide. Here, a comprehensive literature search involving a total of 35 articles with 55 patients was conducted in this paper. We reviewed and analyzed the associated clinical and pathological characteristics, the efficacy of various treatment options and the prognosis. Pulmonary NC mainly occurred in middle young-aged men (median age, 36) with no smoking history (2:1) and would present wi

SUBMITTER: Yuan J 

PROVIDER: S-EPMC9600367 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature