Circadian Rhythm Disruption as a Contributor to Racial Disparities in Prostate Cancer.

ABSTRACT: In the United States, African American (AA) men have a 2.4 times higher mortality rate due to prostate cancer than White men. The multifactorial causes of the racial disparities in prostate cancer involve various social determinants of health, socioeconomic status, and access to healthcare. However, emerging evidence also suggests that circadian rhythm disruption (CRD) contributes to prostate cancer, and AA men may be more susceptible to developing CRDs. Circadian rhythms play a significant role in metabolism, hormone secretion, and sleep/wake cycles. Disruption in these circadian rhythms can be caused by airplane travel/jetlag, night shift work, exposure to light, and neighborhood noise levels, which can contribute to sleep disorders and chronic conditions such as obesity, diabetes, cardi

SUBMITTER: Dasari SS 

PROVIDER: S-EPMC9600368 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature