Cobamide Sharing Is Predicted in the Human Skin Microbiome.

ABSTRACT: The skin microbiome is a key player in human health, with diverse functions ranging from defense against pathogens to education of the immune system. While recent studies have begun to shed light on the valuable role that skin microorganisms have in maintaining the skin barrier, a detailed understanding of the complex interactions that shape healthy skin microbial communities is limited. Cobamides, the vitamin B₁₂ class of cofactor, are essential for organisms across the tree of life. Because this vitamin is only produced by a limited fraction of prokaryotes, cobamide sharing is predicted to mediate community dynamics within microbial communities. Here, we provide the first large-scale metagenomic assessment of cobamide biosynthesis and utilization in the skin microbiome. We sho

SUBMITTER: Swaney MH 

PROVIDER: S-EPMC9600381 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature