The Apportionment of Pharmacogenomic Variation: Race, Ethnicity, and Adverse Drug Reactions.

ABSTRACT: Fifty years ago, Richard Lewontin found that the vast majority of human genetic variation falls within (~85%) rather than between (~15%) racial groups. This result has been replicated numerous times since and is widely taken to support the notion that genetic differences between racial groups are trivial and thus irrelevant for clinical decision-making. The aim of this study was to consider how the apportionment of pharmacogenomic variation within and between racial and ethnic groups relates to risk disparities for adverse drug reactions. We confirmed that the majority of pharmacogenomic variation falls within (97.3%) rather than between (2.78%) the three largest racial and ethnic groups in the United States: Black, Hispanic, and White. Nevertheless, pharmacogenomic variants showing far gr

SUBMITTER: Jordan IK 

PROVIDER: S-EPMC9600569 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature