Plasmodium falciparum Genetic Diversity in Coincident Human and Mosquito Hosts.

ABSTRACT: Population genetic diversity of Plasmodium falciparum antigenic loci is high despite large bottlenecks in population size during the parasite life cycle. The prevalence of genetically distinct haplotypes at these loci, while well characterized in humans, has not been thoroughly compared between human and mosquito hosts. We assessed parasite haplotype prevalence, diversity, and evenness using human and mosquito P. falciparum infections collected from the same households during a 14-month longitudinal cohort study using amplicon deep sequencing of two antigenic gene fragments (ama1 and csp). To a prior set of infected humans (n = 1,175/2,813; 86.2% sequencing success) and mosquito abdomens (n = 199/1,448; 95.5% sequencing success), we added sequences from infected

SUBMITTER: Lapp Z 

PROVIDER: S-EPMC9600619 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature