Immune Imprinting Drives Human Norovirus Potential for Global Spread.

ABSTRACT: Understanding the complex interactions between virus and host that drive new strain evolution is key to predicting the emergence potential of variants and informing vaccine development. Under our hypothesis, future dominant human norovirus GII.4 variants with critical antigenic properties that allow them to spread are currently circulating undetected, having diverged years earlier. Through large-scale sequencing of GII.4 surveillance samples, we identified two variants with extensive divergence within domains that mediate neutralizing antibody binding. Subsequent serological characterization of these strains using temporally resolved adult and child sera suggests that neither candidate could spread globally in adults with multiple GII.4 exposures, yet young children with minimal GII.4 expo

SUBMITTER: Lindesmith LC 

PROVIDER: S-EPMC9600701 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature