Use of Proton Pump Inhibitors and the Risk for the Development of Gastric Cancers: A Nationwide Population-Based Cohort Study Using Balanced Operational Definitions.

ABSTRACT:

Objectives

Previous cohort studies using national claim data in Korea have shown conflicting results about the association between the use of proton pump inhibitors (PPIs) and the risk of gastric cancer. This may be due to differences in the inclusion criteria or index dates of each study. This study aims to evaluate the association between PPI use and the risk of gastric cancer using balanced operational definitions.

Design

A population-based cohort analysis was conducted using the Korean National Health Insurance Service database. Subjects who used PPIs or histamine-2 receptor antagonist (H₂RA) for more than 60 days after Helicobacter pylori eradication were included. The study subjects were those who had never used H₂RAs (PPI users) and contro

SUBMITTER: Gong EJ 

PROVIDER: S-EPMC9600864 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature