The Pharmacogenetics of Cannabis in the Treatment of Chronic Pain.

ABSTRACT:

Background

The increase in the medical use of cannabis has revealed a number of beneficial effects, a variety of adverse side effects and great inter-individual variability. Association studies connecting consumption, addiction and side effects related to recreational cannabis use have led to the identification of several polymorphic genes that may play a role in the pharmacodynamics and pharmacokinetics of cannabis.

Method

In total, 600 patients treated with cannabis were genotyped for several candidate polymorphic genes (single-nucleotide polymorphism; SNP), encoding receptors CNR1 and TRPV1; for the ABCB1 transporter; for biotransformation, bioactivation and biosynthesis; and CYP3A4, COMT and UGT2B7 conjugation.

Results

Three polymorphic genes (ABCB1, TRPV1 and UGT

SUBMITTER: Poli P 

PROVIDER: S-EPMC9601332 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature