Exploratory analysis of interleukin-38 in hospitalized COVID-19 patients.

ABSTRACT:

Introduction

A major contributor to coronavirus disease 2019 (COVID-19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin-38 (IL-38) is an IL-1 family member with broad anti-inflammatory properties, but thus far little is known about its role in viral infections. Recent studies have shown inconsistent results, as one study finding an increase in circulating IL-38 in COVID-19 patients in comparison to healthy controls, whereas two other studies report no differences in IL-38 concentrations.

Methods

Here, we present an exploratory, retrospective cohort study of circulating IL-38 concentrations in hospitalized COVID-19 patients admitted to two Dutch hospitals (discovery n = 148 and validation n = 184) and age- and sex-matched healthy su

SUBMITTER: de Graaf DM 

PROVIDER: S-EPMC9601778 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature