High concentration of dopamine treatment may induce acceleration of human sperm motility.

ABSTRACT:

Purpose

In humans, catecholamines (including dopamine) have been identified in semen and fallopian tubes, while dopamine D2 receptors (D2DR) are found in the sperm midpiece region. How dopamine dose affects human sperm function and whether dopamine treatment is useful in assisted reproductive technology is unclear.

Methods

Sperm samples were obtained from patients with normal semen parameters undergoing fertility treatment. We investigated the effects of dopamine treatment on tyrosine phosphorylation and sperm motility. Sperm motility was analyzed using the computer-assisted sperm analysis (CASA) system.

Results

This study revealed that various dopamine concentrations (0.1-100 μM) did not increase sperm tyrosine phosphorylation. Progressive motility increased substant

SUBMITTER: Kanno H 

PROVIDER: S-EPMC9601866 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature