Estimation of Metabolic Effects upon Cadmium Exposure during Pregnancy Using Tensor Decomposition.

ABSTRACT: A simple tensor decomposition model was applied to the liver transcriptome analysis data to elucidate the cause of cadmium-induced gene overexpression. In addition, we estimated the mechanism by which prenatal Cd exposure disrupts insulin metabolism in offspring. Numerous studies have reported on the toxicity of Cd. A liver transcriptome analysis revealed that Cd toxicity induces intracellular oxidative stress and mitochondrial dysfunction via changes in gene expression, which in turn induces endoplasmic reticulum-associated degradation via abnormal protein folding. However, the specific mechanisms underlying these effects remain unknown. In this study, we found that Cd-induced endoplasmic reticulum stress may promote increased expression of tumor necrosis factor-α (TNF-α). Based on the hi

SUBMITTER: Amakura Y 

PROVIDER: S-EPMC9602417 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature