Distinct HIV-1 Population Structure across Meningeal and Peripheral T Cells and Macrophage Lineage Cells.

ABSTRACT: HIV-1 sequence population structure among brain and nonbrain cellular compartments is incompletely understood. Here, we compared proviral pol and env high-quality consensus single-molecule real-time (SMRT) sequences derived from CD3⁺ T cells and CD14⁺ macrophage lineage cells from meningeal or peripheral (spleen, blood) tissues obtained at autopsy from two individuals with viral suppression on antiretroviral therapy (ART). Phylogenetic analyses showed strong evidence of population structure between CD3⁺ and CD14⁺ virus populations. Distinct env variable-region characteristics were also found between CD3⁺ and CD14⁺ viruses. Furthermore, shared macrophage-tropic amino acid residues (env) and drug re

SUBMITTER: Rose R 

PROVIDER: S-EPMC9602438 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature