Research into the Bioengineering of a Novel α-Conotoxin from the Milked Venom of Conus obscurus.

ABSTRACT: The marine cone snail produces one of the fastest prey strikes in the animal kingdom. It injects highly efficacious venom, often causing prey paralysis and death within seconds. Each snail has hundreds of conotoxins, which serve as a source for discovering and utilizing novel analgesic peptide therapeutics. In this study, we discovered, isolated, and synthesized a novel α3/5-conotoxins derived from the milked venom of Conus obscurus (α-conotoxin OI) and identified the presence of α-conotoxin SI-like sequence previously found in the venom of Conus striatus. Five synthetic analogs of the native α-conotoxin OI were generated. These analogs incorporated single residue or double residue mutations. Three synthetic post-translational modifications (PTMs) were synthetically incorpora

SUBMITTER: Wiere S 

PROVIDER: S-EPMC9602734 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature