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Legionella quinlivanii strain isolated from a human: A case report and whole genome sequencing analysis.

ABSTRACT: We describe a strain of Legionella quinlivanii isolated from a bronchoalveolar lavage specimen from an 83-year-old patient in the province of Québec. Identification was done using 16S rRNA sequencing. The strain could replicate efficiently in human THP-1 macrophages and maintained a low level of cytotoxicity. Upon analyzing the whole genome sequencing data, the icm/dot secretion system was present, but the strain lacked some effector genes known to express proteins toxic to cells. The pathogenicity of this Legionella species should be investigated further.

SUBMITTER: Lalancette C

PROVIDER: S-EPMC9602882 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Legionella quinlivanii strain isolated from a human: A case report and whole genome sequencing analysis.

Lalancette Cindy C Leduc Jean-Michel JM Malo Jacques J Fournier Éric É Saoud Joseph J Faucher Sébastien P SP Pacheco Ana Luisa AL Bernard Kathryn K Martineau Christine C Lévesque Simon S

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada 20200623 2

We describe a strain of Legionella quinlivanii isolated from a bronchoalveolar lavage specimen from an 83-year-old patient in the province of Québec. Identification was done using 16S rRNA sequencing. The strain could replicate efficiently in human THP-1 macrophages and maintained a low level of cytotoxicity. Upon analyzing the whole genome sequencing data, the icm/dot secretion system was present, but the strain lacked some effector genes known to express proteins toxic to cells. ...[more]

PMID: 36338178

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