Does Intrauterine Injection of hCG Improve IVF Outcome? A Systematic Review and a Meta-Analysis.

ABSTRACT: Various interventions have been proposed to improve embryo implantation in IVF. Among these, intrauterine injections of human chorionic gonadotropin seem to have promising results. Consequently, we conducted a review and meta-analysis to assess IVF outcomes by comparing couples who underwent intrauterine hCG injection transfer versus those who underwent embryo transfer with intrauterine injection of placebo, or without any additional intervention. The primary outcome was the clinical pregnancy rate. Secondary outcomes were the implantation rate, miscarriage rate, and live birth rate. A meta-analysis was conducted using the random effects model, while bias within studies was detected using the Cochrane risk of bias tool. Ectopic pregnancies and stillbirths were also assessed. The clinical p

SUBMITTER: Conforti A 

PROVIDER: S-EPMC9603006 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature