Genomic analysis of group A Streptococcus isolated during a correctional facility outbreak of MRSA in 2004.

ABSTRACT:

Background

In 2004-2005, an outbreak of impetigo occurred at a correctional facility during a sentinel outbreak of methicillin- resistant Staphylococcus aureus (MRSA) in Alberta, Canada. Next-generation sequencing (NGS) was used to characterize the group A Streptococcus (GAS) isolates and evaluate whether genomic biomarkers could distinguish between those recovered alone and those co-isolated with S. aureus.

Methods

Superficial wound swabs collected from all adults with impetigo during this outbreak were cultured using standard methods. NGS was used to characterize and compare all of the GAS and S. aureus genomes.

Results

Fifty-three adults were culture positive for GAS, with a subset of specimens also positive for MRSA (n = 5) or me

SUBMITTER: Lynch T 

PROVIDER: S-EPMC9603014 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature