Lysine Acetylome Profiling Reveals Diverse Functions of Acetylation in Deinococcus radiodurans.

ABSTRACT: Lysine acetylation is a highly conserved posttranslational modification that plays essential roles in multiple biological functions in a variety of organisms. Deinococcus radiodurans (D. radiodurans) is famous for its extreme resistance to radiation. However, few studies have focused on the lysine acetylation in D. radiodurans. In the present study, antibody enrichment technology and high-resolution liquid chromatography mass spectrometry are used to perform a global analysis of lysine acetylation of D. radiodurans. We create the largest acetylome data set in D. radiodurans to date, totally identifying 4,364 lysine acetylation sites on 1,410 acetylated proteins. Strikingly, of the 3,085 proteins annotated by the uniport database, 45.7% of proteins are acetylated in D. radiodurans. In parti

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9603093 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature