Excessive Adventitial and Perivascular Vascularisation Correlates with Vascular Inflammation and Intimal Hyperplasia.

ABSTRACT: Albeit multiple studies demonstrated that vasa vasorum (VV) have a crucial importance in vascular pathology, the informative markers and metrics of vascular inflammation defining the development of intimal hyperplasia (IH) have been vaguely studied. Here, we employed two rat models (balloon injury of the abdominal aorta and the same intervention optionally complemented with intravenous injections of calciprotein particles) and a clinical scenario (arterial and venous conduits for coronary artery bypass graft (CABG) surgery) to investigate the pathophysiological interconnections among VV, myeloperoxidase-positive (MPO⁺) clusters, and IH. We found that the amounts of VV and MPO⁺ clusters were strongly correlated; further, MPO⁺ clusters density was sign

SUBMITTER: Bogdanov L 

PROVIDER: S-EPMC9603343 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature